Preclinical Safety Profile of an Oral Naringenin/Hesperidin Dosage Form by In Vivo Toxicological Tests

نویسندگان

چکیده

We developed a naringenin–hesperidin molar mixture (MIX–160) with proven antihyperglycemic and vasorelaxant activity in preclinical studies. A solid dosage form was manufactured to improve the bioavailability properties. In current study, we sought evaluate oral toxicity of MIX–160 form, which showed no mortality or significant changes body weight, food consumption tissue/organ mass rats. Three daily doses (50, 300 2000 mg/kg MIX–160) were assayed for 28 days. The results structural abnormalities histological analysis (p > 0.05) liver biochemical markers (total bilirubin, AST ALT) compared control group. above findings that did not exhibit relevant toxic effects, suggests its potential safety as drug candidate clinical

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ژورنال

عنوان ژورنال: Scientia Pharmaceutica

سال: 2022

ISSN: ['0036-8709', '2218-0532']

DOI: https://doi.org/10.3390/scipharm90020028